![]() Received: ApAccepted: AugPublished: September 18, 2013Ĭopyright: © 2013 Soria et al. PLoS ONE 8(9):Įditor: Ken Arai, Massachusetts General Hospital/Harvard Medical School, United States of America (2013) The Ins and Outs of the BCCAo Model for Chronic Hypoperfusion: A Multimodal and Longitudinal MRI Approach. In summary, BCCAo in rats induces specific signatures in multimodal MRI that are compatible with various types of histological lesion and with marked adaptive arteriogenesis.Ĭitation: Soria G, Tudela R, Márquez-Martín A, Camón L, Batalle D, Muñoz-Moreno E, et al. The structural alterations found in the basilar artery were compatible with compensatory adaptive changes driven by shear stress. Independently of brain damage, BCCAo induced progressive arteriogenesis in the vertebrobasilar tree, a process that was associated with blood flow recovery after 12 weeks. The latter interfered with the visually cued learning paradigms used to test executive functions. Progressive microstructural changes revealed by diffusion tensor imaging in white matter were confirmed by observation of myelinated fiber degeneration, including severe optic tract degeneration. The patterns of MRI alterations were related to either ischemic necrosis or gliosis. Independently, delayed MRI changes were also apparent. MRI frequently (70%) showed various degrees of acute ischemic lesions, ranging from very small to large subcortical infarctions. Changes in MRI were related to behavioral performance in executive function tasks and histopathological alterations in the same animals. Here we implemented a longitudinal multimodal magnetic resonance imaging (MRI) design, including time-of-flight angiography, high resolution T1-weighted images, T2 relaxometry mapping, diffusion tensor imaging, and cerebral blood flow measurements up to 12 weeks after BCCAo or sham-operation in Wistar rats. However, the histopathological and behavioral alterations reported in this model are variable and a full characterization of the dynamic alterations is not available. Cerebral hypoperfusion induced by bilateral common carotid artery occlusion (BCCAo) in rodents has been proposed as an experimental model of white matter damage and vascular dementia.
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